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Also, while the manufacturers of metformin recommend against breastfeeding while taking the drug, data have shown that metformin is excreted into breast milk in small amounts and adverse effects on infant plasma glucose have not been reported in human studies

Important caveat: human efficacy is unproven

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Transcriptomic analyses of laser capture microdissected neurons from postmortem human AD revealed that NFT-containing neurons expressed signaling pathways consistent with cellular senescence, including SCAPs, upreguled pro-survival and inflammatory pathways and downregulated cell death pathways (35)